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Antibody Drug Discovery Accelerator

Antibody drug discovery business module focused on nanobody preparation,construction of phage antibody library、antibody screening and sequencing、construction of library and high-throughput recombinant antibody expression purification

IVD raw material customization

Separation and Purification of High-Quality Antigens in Eukaryotic and Prokaryotic Multi-Host Systems,Alpaca single domain antibody,Rabbit monoclonal and mouse monoclonal antibody customization services.

Subunit vaccine development

Comprehensive genetic engineering vaccine development system,Anti-idiotypic antibody vaccine program,Cooperative development and technology transfer and other cooperation modes.

Development of animal and plant disease detection reagents

Provides livestock/avian/forest/fishery disease detection solutions,Good atColloidal gold test stripandELISA kitDevelopment


Provide one-stop project services for the medical field,The content covers the topic design、experimental verification、result analysis and paper writing services。

Research services

Providing tens of thousands of scientific research workers with basic scientific research services such as vector construction, gene detection, protein expression purification and macromolecular interaction

Special service&product

There were succor of the way,and the industry had special specialties,featured service of Zoonbio ranks in the forefront of the industry

Alpaca Nanobody Preparation Service

Alpaca Breeding Base, with more than 20 alpacas of healthy age, clear immune background, paternity provenance, equipped with professional veterinarians and breeding facilities.

Lactobacillus protein expression service

Based on Nisin-induced NICE system lactic acid bacteria expression platform, provides a variety of expression programs, including heat-induced expression, food-grade expression, and secretory expression.

Plant hormone testing services

Accurately and efficiently detect changes in plant hormones using LC-MS。The isotope internal standard used, compared with the external standard method, the result is more objective and true.

Super "flash blue" SDS-PAGE stain

Completely replace the traditional dyeing method, instant blue staining solution is non-toxic, odorless, green, 5 minutes dyeing complete SDS-PAGE, save time and effort.

Published documents

Protein expression

* Identification and validation of reference genes for quantitative real-time PCR studies in long yellow daylily, Hemerocallis citrina Borani. Feifan hou.PLoS One. 2017, doi: 10.1371/journal.pone.0174933
* Transcriptional profiling analysis of Spodoptera litura larvae challenged with Vip3Aa toxin and possible involvement of trypsin in the toxin activation.Feifei Song et.al.Sci Rep. 2016; 6: 23861.doi: 10.1038/srep23861
* Activation of PPARγ by a Natural Flavonoid Modulator, Apigenin Ameliorates Obesity-Related Inflammation Via Regulation of Macrophage Polarization.et al.Xiujing Feng et al.EBioMedicine. 2016 Jul; 9: 61–76.doi:10.1016/j.ebiom.2016.06.017
* Molecular characterisation of the vitellogenin gene (AlVg) and its expression after Apolygus lucorum had fed on different hosts. Sun Y et al. Pest Management Science, Volume 72, Issue 9, 22 JAN 2016.
* Hydrogen Sulfide Regulates Krüppel‐Like Factor 5 Transcription Activity via Specificity Protein 1 S‐Sulfhydration at Cys664 to Prevent Myocardial Hypertrophy.Guoliang Meng et al. J Am Heart Assoc. 2016 Sep; 5(9): e004160.doi: 10.1161/JAHA.116.004160
* Identification and Comparative Analysis of CBS Domain-Containing Proteins in Soybean (Glycine max) and the Primary Function of GmCBS21 in Enhanced Tolerance to Low Nitrogen Stress.Qingnan Hao et al.Int J Mol Sci. 2016 May; 17(5): 620.doi: 10.3390/ijms17050620
* Expression and prognostic value of E-cadherin in laryngeal cancer. Xiaoyun Qian et al, Acta Oto-Laryngologica Volume 136, 2016 - Issue 7.
* Preparation and characterization of a stable BHK-21 cell line constitutively expressing the Schmallenberg virus nucleocapsid protein. Yongning Zhang et al. Molecular and Cellular Probes Volume 29, Issue 4, August 2015, 244–253
* Recombinant rat CC16 protein inhibits LPS-induced MMP-9 expression via NF-κB pathway in rat tracheal epithelial cells. Min Pang et al.Exp Biol Med (Maywood). 2015 Oct; 240(10): 1266–1278.doi: 10.1177/1535370215570202
* ROS activates JNK-mediated autophagy to counteract apoptosis in mouse mesenchymal stem cells in vitro.Guanyu Liu et.al.Acta Pharmacol Sin. 2015 Dec; 36(12): 1473–1479. doi: 10.1038/aps.2015.101
* ER Stress Mediates TiAl6V4 Particle-Induced Peri-Implant Osteolysis by Promoting RANKL Expression in Fibroblasts.Zhenheng Wang.et al.PLoS One. 2015; 10(9)doi: 10.1371/journal.pone.0137774.
* Characterizing heat shock protein 90 gene of Apolygus lucorum (Meyer-Dür) and its expression in response to different temperature and pesticide stresses. Yang Sun. et.al.Cell Stress Chaperones. 2014 Sep; 19(5): 725–739.doi: 10.1007/s12192-014-0500-0
* Cloning and prokaryotic expression of GmNAC8 gene isolated from soybean.LIU Xiao-qing et al. Jiangsu Journal of Agricultural Sciences,2014, 04.
* Expression and purification of soluble human APRIL in Ecoli using ELP-SUMO tag. Zhang J. et al.Protein Expr Purif. 2014 Mar;95:177-81. doi: 10.1016/j.pep.2013.12.013. Epub 2014 Jan 10.

Molecular biology

* Molecular characterization and detection of a spontaneous mutation conferring imidazolinone resistance in rapeseed and its application in hybrid rapeseed production. Hu, M., Pu, H., Kong, L. et al. Mol Breeding (2015) 35: 46. doi:10.1007/s11032-015-0227-3.
* MoDnm1 Dynamin Mediating Peroxisomal and Mitochondrial Fission in Complex with MoFis1 and MoMdv1 Is Important for Development of Functional Appressorium in Magnaporthe. oryzae. Kaili Zhong el.al. PLoS Pathog. 2016 Aug; 12(8): e1005823.doi: 10.1371/journal.ppat.1005823
* Effect of Removing Superior Spikelets on Grain Filling of Inferior Spikelets in Rice. Cuicui You et al. Front Plant Sci. 2016; 7: 1161. Published online 2016 August 5. doi: 10.3389/fpls.2016.01161
* Identification and validation of reference genes for quantitative real-time PCR studies in long yellow daylily, Hemerocallis citrina Borani. Feifan Hou et al.PLoS One. 2017; 12(3): e0174933. doi: 10.1371/journal.pone.0174933
* KR3和Hs1基因聚合对大豆花叶病毒病抗性的影响 Yu XQ. Zhejiang University, 2016.
* 家蚕c-Myc基因的全长cDNA克隆及促细胞增殖功能初探 Xu Hanfu et al.State Key Laboratory of Silkworm Genome Biology,Southwest University; Science of Sericulture,2015 February.
* Isolation and characterization of a proteinaceous α-amylase inhibitor AAI-CC5 from Streptomyces sp. CC5, and its gene cloning and expression.Sun, Z., Lu, W., Liu, P. et al. Antonie van Leeuwenhoek (2015) 107: 345. doi:10.1007/s10482-014-0333-y.
* 猪带绦虫双歧杆菌表达系统pGEX-TSOL18/B.longum的构建及鉴定 Zhou Bi-ying et al. Department of Parasitology,Zunyi Medical College. Chinese Journal of Parasitology and Parasitic Diseases. 2014 March.
* 家蚕卵黄原蛋白受体BmVgR的体外表达 Luo Juan et al, Scientia Agricultura Sinica, 2014 19.
* Deng Y et al.The role of miR-31-modified adipose tissue-derived stem cells in repairing rat critical-sized calvarial defects.2013 Sep;34(28):6717-28. doi: 10.1016/j.biomaterials.2013.05.042. Epub 2013 Jun 13.
* Deng Y et al. Effects of a miR-31, Runx2, and Satb2 regulatory loop on the osteogenic differentiation of bone mesenchymal stem cells.2013 Aug 15;22(16):2278-86. doi: 10.1089/scd.2012.0686. Epub 2013 Apr 27.


Antibody preparation and immunoassay/span>

* Luteoloside Acts as 3C Protease Inhibitor of Enterovirus 71 In Vitro.Zeyu Cao et al.PLoS One. 2016; 11(2): e0148693.doi: 10.1371/journal.pone.0148693
* 禾谷镰刀菌几丁质合成酶的功能研究 Zhang XP. Zhejiang University, 2016. (Southern Blot)
* Recombinant rat CC16 protein inhibits LPS-induced MMP-9 expression via NF-κB pathway in rat tracheal epithelial cells.Min Pang et al.Exp Biol Med (Maywood). 2015 Oct; 240(10): 1266–1278.doi: 10.1177/1535370215570202
* Biotic stress-induced expression of mulberry cystatins and identification of cystatin exhibiting stability to silkworm gut proteinases. Liang, J., Wang, Y., Ding, G. et al. Planta (2015) 242: 1139. doi:10.1007/s00425-015-2345-x.
* 醋酸棉酚对人舌鳞癌Tca8113细胞hMLH1蛋白及mRNA表达的影响 Chen WF et al. Journal of Kunming Medical University, 2014, 01.
* Xin Wang, Ping Zhao, Yi Li, Qiying Yi, Sanyuan Ma, Kang Xie, Huifang Chen, Qingyou Xia*. Modifying the mechanical properties of silk fiber by genetically disrupting the ionic environment for silk formation. Biomacromolecules, 2015.
* 金属离子和离子转运蛋白在蚕丝成纤过程中的功能研究 Wang X. Southwest University,2016.
* 白蜡虫脂酰辅酶A还原酶多克隆抗体的制备 Hu YH et al. Forest Research, 2014, 01.
* 草鱼呼肠孤病毒HZ08株S10编码蛋白多克隆抗体制备及其特性分析 Li YG et al. Journal of Fisheries of China, 2014, 03.
* 异常凝血酶DCP基因克隆表达、纯化及单克隆抗体制备与鉴定 Shen P et al. World Chinese Journal of Digestology, 35.
* 新型Resilin-R5融合蛋白的大肠杆菌表达和纯化 Mao ZZ. Acta Agriculturae Zhejiangensis, 2014, 01.
* 罗非鱼无乳链球菌LrrG蛋白的原核表达及免疫原性分析 Chen Xue et al. Journal of Fisheries of Chinsa, 2014, 05.
* 猪带绦虫TSO45W-4B基因的克隆、表达和抗体制备 Zhou BY et al. Chinese Journal of Parasitology and Parasitic Diseases, 2013, 05.
* 猪带绦虫TSOL18基因的表达、纯化和兔抗血清的制备 Zhou BY et al. Chinese Journal of Zoonoses, 2013, 10.
Simultaneous Detection of Fenitrothion and Chlorpyrifos-Methyl with a Photonic Suspension Array.Xuan Wang et al.PLoS One. 2013; 8(6): e66703. doi: 10.1371/journal.pone.0066703
* 罗非鱼无乳链球菌C5a肽酶的原核表达及其免疫原性研究 Li QY. Shanghai Ocean University, 2013.
* 小鼠肝炎病毒N蛋白单克隆抗体的制备及鉴定 Zhou J et al. Chinese Journal of Cellular and Molecular Immunology, 2012, 08.



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